Succinate Induces Liver Damage and Hepatic Fibrosis in a Mouse Model

Hepatic stellate cells (HSCs) play a key role in liver fibrosis. Succinate and succinate receptor (GPR91) signaling pathway are involved the activation, proliferation, migration of HSCs. We investigated whether may induce hepatic The mice were randomly divided into 2 groups —the control group (chow diet-fed mice, n = 26) sodium (2% + chow diet, 38). Each diet was provided for 16 weeks. Mice administered an oral 2% sixteen weeks lost body weight had increased serum alanine transaminase triglyceride contents compared to those mice. Moreover, fed with showed expression alpha smooth muscle actin protein gene at 8 feeding fibrosis their histology feeding. However, GPR91 mRNA 4 feeding, but decreased These results suggest that could damage might be early marker or sensor development.